发明名称 |
Sustained-release microparticle preparation of human growth hormone and process for producing thereof |
摘要 |
Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent as much as possible, allows the sustained-release of a human growth hormone over 3 days or more and reduction in the initial burst release, can contain a human growth hormone at 10% or more, can quantitatively adsorb and encapsulate a human growth hormone at up to 20%, and has excellent dispersion and needle penetration properties. A process for producing the sustained-release microparticle preparation of a human growth hormone is also provided. The sustained-release microparticle preparation comprises a porous apatite derivative, a human growth hormone, and a water-soluble divalent metal compound.
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申请公布号 |
US2006258575(A1) |
申请公布日期 |
2006.11.16 |
申请号 |
US20050554574 |
申请日期 |
2005.10.27 |
申请人 |
OGAWA YASUAKI;FUJII TAKAO;MIYAMOTO YOKO;NIIMI JUN;IKOMA TOSHIYUKI;TANAKA JUNZO |
发明人 |
OGAWA YASUAKI;FUJII TAKAO;MIYAMOTO YOKO;NIIMI JUN;IKOMA TOSHIYUKI;TANAKA JUNZO |
分类号 |
A61K9/52;A61K38/27;A61K9/16;A61K9/22;A61K47/02;A61K47/04;A61P5/10 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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