PKA II ANCHORING DISRUPTION POLYPEPTIDE

摘要

A PKA II anchoring disruption molecule or AKAP mimic, wherein said molecule or mimic is a polypeptide which comprises the following amino acid sequence: X₁ X₂ E X₃ X₄ A K Q I V X₅ X₆ X₇ I X₈ X₉ X₁₀ (sequence (1) ) or a peptidomimetic or analogue thereof is provided. Also provided are antibodies to the molecule, nucleic acid molecules comprising a sequence encoding the molecule and pharmaceutical compositions. A method of altering the PKA type II signalling pathway in a cell by administration of the anchoring disruption molecule or AKAP mimic, in particular to treat cardiovascular and metabolic disorders is also provided.