DERIVADOS 2'-O-SILIL TRISSUBSTITUIDO-OXIMETIL-RIBONUCLEOSIDO E METODO PARA A SUA PREPARACAO

摘要

The invention provides ribonucleoside derivatives with novel protecting groups and methods for the preparation of such ribonucleoside derivatives. The general formula (I) of the ribonucleoside derivatives is: wherein R₁ is a base of the purine- or pyrimidine-family or a derivative of such a base or any other residue with serves as a nucleobase surrogate, R₂ is a proton or a substituted derivative of phosphonic acid, R₃ is a proton or a protection-group for the oxygen atom in 5'-position, R₄, R₅ and R₆ are independently alkyl or aryl or a combination of alkyl and aryl or heteroatom, R₄, R₅ or R₆ may also be cyclically connected to each other; and wherein at least one of the R₄, R₅ or R₆ substituents comprises a tertiary C-atom or a heteroatom vicinal to the Si-atom.