发明名称 |
Hydrolytically degradable alkylene oxide based polymers |
摘要 |
The present invention provides a water soluble, nonpeptidic polymer comprising two or more alkylene oxide-based oligomers linked together by hydrolytically degradable linkages such as carbonates. Typically, the oligomer portion of the polymer is an amphiphilic triblock copolymer having a central propylene oxide block or butylene oxide block positioned between two ethylene oxide blocks. The polymer can be hydrolytically degraded into oligomers under physiological conditions. In aqueous media, the polymer preferably forms thermally reversible, hydrolytically degradable hydrogels that can be used, for example, for drug delivery and related biomedical applications.
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申请公布号 |
US2006239961(A1) |
申请公布日期 |
2006.10.26 |
申请号 |
US20030371996 |
申请日期 |
2003.02.14 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION |
发明人 |
BENTLEY MICHAEL D.;HARRIS J. M.;ZHAO XUAN;BATTLE WILLIAM D.III;SHEN SIAOMING |
分类号 |
A61K31/785;A61K47/34;C08G8/28;C08G64/18;C08G65/329;C08G65/333 |
主分类号 |
A61K31/785 |
代理机构 |
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