NOVEL EFFICIENT PRODUCTION PROCESS FOR CAPSULAR POLYSACCHARIDES OF PATHOGENIC GRAMPOSITIVE BACTERIA BY HETEROLOGOUS EXPRESSION AND SECRETION OF COMPLEX POLYSACCHARIDES IN NON-PATHOGENIC, NON-INVASIVE GRAM- POSITIVE BACTERIA

摘要

The current invention provides methods and means for heterologous expression, production and/or secretion of complex capsular polysaccharides in non- pathogenic, non-invasive Gram-positive bacteria. The invention in particular provides non- pathogenic, non- invasive Gram-positive bacteria capable of expression and/or secretion of heterologous, complex polysaccharides from a pathogenic bacterial species. Such bacteria and polysaccharides produced therein may be applied according to the invention to provide compositions for vaccination for the treatment and prevention of infectious bacterial diseases.