HIV-gag codon-optimised DNA vaccines

摘要

The invention provides a nucleotide sequence that encodes an HIV-1 gag protein or fragment thereof containing a gag epitope, an HIV-1 Nef protein or a fragment containing a Nef epitope thereof, and an RT protein or a fragment containing an RT epitope thereof, operably linked to a heterologous promoter, wherein the order of the sequence is Gag, RT, Nef.