发明名称 |
DRUG-CONTAINING NANOPARTICLE, PROCESS FOR PRODUCING THE SAME AND PARENTERALLY ADMINISTERED PREPARATION FROM THE NANOPARTICLE |
摘要 |
To provide an external preparation or injectable preparation that exerts the effect of enabling transdermal or transmucosal in vivo absorption of fat-soluble drugs and water-soluble drugs not having been satisfactorily attained hitherto and that contains a highly absorbable fat-soluble/water-soluble drug, the injectable preparation especially aiming at sustained-release and target effects. In particular, drug-containing nanoparticles (secondary nanoparticles) are provided by causing primary nanoparticles containing a fat-soluble drug or fat-solubilized water-soluble drug to act with a bivalent or trivalent metal salt. Further, drug-containing nanoparticles (tertiary nanoparticles) are provided by first causing primary nanoparticles containing a fat-soluble drug or fat-solubilized water-soluble drug to act with a bivalent or trivalent metal salt to thereby obtain secondary nanoparticles and thereafter causing a monovalent to trivalent basic salt to act on the secondary nanoparticles. Still further, there are provided a process for producing these nanoparticles, and a transdermal or transmucosal external preparation or injectable preparation in which these nanoparticles are contained.
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申请公布号 |
EP1698329(A1) |
申请公布日期 |
2006.09.06 |
申请号 |
EP20040792270 |
申请日期 |
2004.10.12 |
申请人 |
LTT BIO-PHARMA CO., LTD. |
发明人 |
ISHIHARA, TSUTOMU;MIZUSHIMA, YUTAKA;SUZUKI, JUN,;SEKINE, JUNZOU;YAMAGUCHI, YOKO;IGARASHI, RIE |
分类号 |
A61K9/14;A61K9/06;A61K9/08;A61K9/10;A61K9/20;A61K9/51;A61K9/70;A61K9/72;A61K31/07;A61K31/122;A61K31/198;A61K47/02;A61K47/04;A61K47/10;A61K47/12;A61K47/24;A61K47/34;A61K47/36;A61P3/02 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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