发明名称 |
Solid formulation with improved solubility and stability, and method for producing said formulation |
摘要 |
The present invention relates to a solid formulation with improved solubility and maintained stability including a chemical substance poorly soluble in water as a pharmaceutically active ingredient formulated in an improved manner. More specifically, the present invention relates to a solid formulation having improved water-solubility which comprises a chemical substance poorly soluble in water as a pharmaceutically active ingredient, a water-soluble polymer substance and an inorganic porous substance, characterized in that (1) the chemical substance poorly soluble in water forms a solid dispersion together with the water-soluble polymer substance, (2) the water-soluble polymer substance forming the solid dispersion is in the form of fine pieces, and (3) the water-soluble polymer substance is in the form of fine pieces is maintained to be adsorbed on and/or adhered to the surface of the inorganic porous substance. The solid formulation can be produced by stirring and mixing a solution obtained by dissolving a chemical substance poorly soluble in water as a pharmaceutically active ingredient and a water-soluble polymer substance in an organic solvent with an inorganic porous substance and then granulating and drying the mixture.
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申请公布号 |
US2006153913(A1) |
申请公布日期 |
2006.07.13 |
申请号 |
US20050256201 |
申请日期 |
2005.10.24 |
申请人 |
YAMANE SHOGO;YAMANE HIROFUMI;SUNAMI MASAKI |
发明人 |
YAMANE SHOGO;YAMANE HIROFUMI;SUNAMI MASAKI |
分类号 |
A61K31/47;A61K9/20;A61K31/454 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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