发明名称 |
Polyarginine-modified liposome having nuclear entry ability |
摘要 |
With the object of providing a liposome having cellular and nuclear entry ability, to achieve this object, a liposome is provided having on its surface a peptide comprising multiple consecutive arginine residues, and specifically a liposome is provided wherein the peptide is modified with a hydrophobic group or hydrophobic compound and the hydrophobic group or hydrophobic compound is inserted into a lipid bilayer so that the peptide is exposed on the surface of the bilayer.
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申请公布号 |
EP1676588(A1) |
申请公布日期 |
2006.07.05 |
申请号 |
EP20040791967 |
申请日期 |
2004.10.01 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
HARASHIMA, HIDEYOSHI;FUTAKI, SHIROH;KOGURE, KENTARO |
分类号 |
A61K47/48;A61K9/127;A61K31/70;A61K31/7048;A61K38/00;A61K47/34;A61K47/42;C07K1/107;C07K7/00;C12N15/88;(IPC1-7):A61K47/42;A61K31/704 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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