摘要 |
The invention relates to a method for coupling a first molecular having a molecular weight of less than 1000 Da to a second molecule having a molecular weight of more than 10 000 Da, characterized in that amide formation of an intermediate compound obtained from the first molecule is carried out, comprising at least one heterocycle and at least one carboxyl group, said amide formation relating to the second molecule. The invention also relates to the intermediate compound occurring in said method, a method for obtaining said intermediate compound, the final product and uses thereof. |