METHOD FOR THE TREATMENT OF DISEASE

摘要

The present invention provides novel methods for the treatment or prevention of diseases and disorders, e.g., cancer, characterized by a mutation in the Nf2 gene. In this method, one or more compounds that inhibit signaling through the EGFR is administered to an individual with Nf2 mutation. In a preferred embodiment the one or more compound is an EGFR inhibitor. Diseases and disorders such as neurofibromatosis type 2 (NF-2) and cancers such as, but not limited to cancers of the nervous system (e.g., Schwann cell tumors, 5-schwannoma, meningioma, or ependymoma) and malignant mesothelioma are treatable by the methods of the present invention.