USE OF TRIGLYCERIDE OILS CONTAINING GAMMA-LINOLENIC ACID RESIDUES AND LINOLEIC ACID RESIDUES FOR THE TREATMENT OF A NEURODEGENERATIVE DISEASE

摘要

A triglyceride oil is provided containing both ³-linolenic acid and linoleic acid residues as triglyceride ester for the treatment of neurodegenerative disease wherein the oil is administered at a dose sufficient to elevate or maintain TGF-²1 levels in the patient to or at a therapeutic level such as to produce a TGF-²1/TNF-± ratio of at least 0.5 in blood of a patient, after 18 months of daily dosing characterised in that the oil is obtained from a fungus of Mucor species; the ratio of ³-linolenic acid to linoleic acid residues at the sn-2 position of the triglyceride is at least 0.8; the amount of ³-linolenic acid residues at the sn-2 position is at least 18%, the dose is sufficient to administer at least 1 gram of ³-linolenic acid residues, as residues in the sn-2 position, excluding other ³-linolenic acid content of the oil.