发明名称 |
Melanoma vaccine and methods of making and using same |
摘要 |
An immunotherapeutic vaccine providing antigen presenting cells that have been pulsed with a disrupted cell preparation which includes enucleated cytosol and cell membranes of cancer cells infected with a recombinant vaccinia virus encoding at least one immunostimulating molecule. In a preferred embodiment, the vaccine includes autologous dendritic/monocytic cells (DC/M) that present a mixture of antigens (present in the enucleated cytosol and cell membranes) from melanoma cell lines that have been infected with a recombinant vaccinia virus encoding IL-2. In another of the preferred embodiments, the enucleated cytosol and cell membranes are from melanoma cells harvested from the patient to be treated. A method of making the vaccine and methods of using the vaccine to stimulate an anti-cancer immune response and to treat a patient with a cancer are also described.
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申请公布号 |
US2006034811(A1) |
申请公布日期 |
2006.02.16 |
申请号 |
US20050188849 |
申请日期 |
2005.07.26 |
申请人 |
WALLACK MARC K;SIVANANDHAM MUTHUKUMARAN |
发明人 |
WALLACK MARC K.;SIVANANDHAM MUTHUKUMARAN |
分类号 |
A61K38/00;A61K48/00;A61K;A61K35/12;A61K35/76;A61K38/20;A61K38/21;A61K38/44;A61K38/45;A61K38/46;A61K39/00;A61K39/275;A61K39/39;A61P35/00;A61P37/00;C12N15/863 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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