BLOCKADE OF MTOR TO PREVENT A HORMONAL ADAPTIVE RESPONSE
摘要
One embodiment of the present invention is directed to the use of an mTOR inhibitor, such as farnesylthiosalicylic acid (FTS), to prevent a hormonal adaptive response during hormonal deprivation treatment of a hormonal responsive cancer. FIG. 4 represents the effect of FTS on E2 stimulated growth of MCF-7 and LTED cells.
申请公布号
WO2005018562(A3)
申请公布日期
2005.12.29
申请号
WO2004US27016
申请日期
2004.08.20
申请人
UNIVERSITY OF VIRGINIA PATENT FOUNDATION;SANTEN, RICHARD, J.;YUE, WEI;LAWRENCE, JOHN, C., JR.;MCMAHON, LLOYD, P.
发明人
SANTEN, RICHARD, J.;YUE, WEI;LAWRENCE, JOHN, C., JR.;MCMAHON, LLOYD, P.
