The present invention relates to compositions comprising at least one purified PorA protein antigen and at least one purified FetA protein antigen. In particular, said PorA/FetA antigens are antigenically variable antigens comprising the variable regions of PorA/FetA. Specific combinations of PorA/FetA epitopes are presented for example in Table 3. The invention also relates to methods of immunisation comprising administering said compositions, and to methods for producing compositions. Preferably the compositions are purified protein compositions. Preferably the compositions are vaccine compositions.
申请公布号
WO2005117956(A2)
申请公布日期
2005.12.15
申请号
WO2005GB02207
申请日期
2005.06.03
申请人
ISIS INNOVATION LIMITED;MAIDEN, MARTIN;FEAVERS, IAN;POLLARD, ANDREW