| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for industrially excellently producing an optically active thalidomide and a derivative thereof. <P>SOLUTION: The optically active thalidomide expressed by formula (3) (R<SP>1</SP>is -CH<SB>2</SB>-, -NH- or -O-; and R<SP>2</SP>to R<SP>7</SP>are identical to or different from one another and are each H, a halogen, hydroxy, a 1-6C alkyl, a 1-6C perhalogenoalkyl, a 1-6C alkoxy, an aryl or amino) or formula (3') and the derivative thereof are, for example, produced by a process (A) for obtaining the compound expressed by formula (3) or formula (3') by making an imide compound expressed by formula (1) or formula (1') react with a phthalic acid anhydride derivative expressed by formula (2) in the presence of hexamethyldisilazane and zinc chloride. <P>COPYRIGHT: (C)2006,JPO&NCIPI</p> |
