NITRIC OXIDE RELEASING COMPOSITIONS AND ASSOCIATED METHODS

摘要

Dendritic nitric oxide donors having the formula: [P]-[(A)y]X [(NO)Z]q wherein P is a core that comprises a biocompatible polymer; A is a branching unit monomer that comprises at least one end group capable of reversibly attaching NO; (NO) is nitric oxide; x, y, and z are positive integers greater than or equal to 1; and q is a positive integer greater than or equal to y, as well as medical devices and kits that comprise dendritic nitirc oxide donors, are provided. Also provided are methods of delivering nitric oxide into a recipient subject comprising: providing a dendritic nitric oxide donor; and administering the dendritic nitric oxide donor into the recipient subject, such that the dendritic nitric oxide donor releases NO in the recipient subject.