发明名称 |
Stable probiotic microsphere compositions and their methods of preparation |
摘要 |
The invention relates to viable and stable probiotic formulations for intestinal targeting made of microspheres comprising each a core of one or more probiotic bacteria, microcrystallline cellulose with a degree of polymerization from 165-365 and mean diameter from 45 to 180 mum, a disintegrant and a stabilizer, the core being coated with a non-enteric coating and further coated with an enteric coating. Each probiotic microsphere has a residual moisture level of less than 5% and a water activity (a<SUB>w</SUB>) between 0.1 and 0.5. Such a probiotic microsphere shows no reduction in viable bacteria after one hour in simulated gastric fluid. The present invention also relates to the process of preparing such formulation.
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申请公布号 |
US2005266069(A1) |
申请公布日期 |
2005.12.01 |
申请号 |
US20030656386 |
申请日期 |
2003.09.05 |
申请人 |
SIMMONS DONALD L;MOSLEMY PEYMAN;PAQUETTE GILLES D;GUERIN DANIEL;JOLY MARIE-HELENE |
发明人 |
SIMMONS DONALD L.;MOSLEMY PEYMAN;PAQUETTE GILLES D.;GUERIN DANIEL;JOLY MARIE-HELENE |
分类号 |
A23L1/00;A23L1/03;A23L1/30;A61K9/16;A61K9/48;A61K9/50;A61K35/74;A61K45/00;A61K45/06;B01J13/04;C12N11/12;(IPC1-7):A61K45/00 |
主分类号 |
A23L1/00 |
代理机构 |
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地址 |
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