IL-23 P19 ANTIGEN ARRAY AND USES THEREOF

摘要

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-23 p19 protein or an IL-23 p19 fragment. More specifically, the invention provides a composition comprising a core particle or, preferably a virus-like particle, and at least one IL-23 p19 protein or at least one IL-23 p19 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.