A catheter (100) with a layer of pain reliever. The catheter (100) includes a proximal end, a distal end, and a tube (150) formed therebetween. The tube (150) has an exterior surface (156) and at least one interior surface defining a lumen extending through the tube (150). The catheter (100) further includes a layer (160) coated on the exterior surface (156) of the tube (150) and formed of a pain relieving material.