NAPHTHALEN VERBINDUNGEN, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN

摘要

Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.