发明名称 |
Nucleic acid molecule encoding homer 1B protein |
摘要 |
A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.
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申请公布号 |
US2005164344(A1) |
申请公布日期 |
2005.07.28 |
申请号 |
US20040008889 |
申请日期 |
2004.12.10 |
申请人 |
WORLEY PAUL F.;TU JIAN C.;XIAO BO;LEAHY DANIEL;BENEKEN JUTTA;LANAHAN ANTHONY A.;BRAKEMAN PAUL R. |
发明人 |
WORLEY PAUL F.;TU JIAN C.;XIAO BO;LEAHY DANIEL;BENEKEN JUTTA;LANAHAN ANTHONY A.;BRAKEMAN PAUL R. |
分类号 |
A61K38/00;C07K14/47;C12N1/21;C12N7/01;(IPC1-7):A61K38/17;C07K14/705;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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