发明名称 |
Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof |
摘要 |
The present invention provides pegylated hemoglobins comprising a thiocarbamoyl-phenyl-polyethylene glycol (PEG) attached to hemoglobin, and comprising a polyethylene glycol (PEG) attached to hemoglobin by an acyl group. The invention also provides methods of preparing pegylated hemoglobins using isothiocyanato phenyl carbamate of PEG and using isothiocyanato phenyl di-PEG carbamate. The invention further provides compositions and blood substitutes comprising pegylated hemoglobins and methods of treating a subject which comprise administering to the subject blood substitutes comprising non-hypertensive pegylated hemoglobins.
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申请公布号 |
US2005159339(A1) |
申请公布日期 |
2005.07.21 |
申请号 |
US20040957200 |
申请日期 |
2004.10.01 |
申请人 |
ACHARYA SEETHARAMA A.;SMITH PAUL K.;MANJULA BELUR N. |
发明人 |
ACHARYA SEETHARAMA A.;SMITH PAUL K.;MANJULA BELUR N. |
分类号 |
C07C331/28;C08B15/06;C08B31/00;C08B37/00;C08B37/02;(IPC1-7):C07K14/805;A61K38/42 |
主分类号 |
C07C331/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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