摘要 |
The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3'-hydroxy analogs, 4'-and/or 6' halo and/or alkoxy analogs, and various 5' substituents that incorporate a cyclic amine moiety. |
申请人 |
ACTIVBIOTICS, INC;VAN DUZER, JOHN, H.;MICHAELIS, ARTHUR, F.;GEISS, WILLIAM, B.;STAFFORD, DOUGLAS, G.;RAKER, JOSEPH;YU, XIANG, Y.;SIEDLECKI, JAMES, M.;YANG, YINGFEI |
发明人 |
VAN DUZER, JOHN, H.;MICHAELIS, ARTHUR, F.;GEISS, WILLIAM, B.;STAFFORD, DOUGLAS, G.;RAKER, JOSEPH;YU, XIANG, Y.;SIEDLECKI, JAMES, M.;YANG, YINGFEI |