Aminomethyl-substituted thiazolobenzimidazole derivative

摘要

This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R¹: an oxygen-containing saturated hetero ring or the like, Alk₁: a lower alkylene, m: 0 or 1, Alk₂: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR⁵, R³: H or the like, and R², R⁴, R⁵, R⁶ and R⁷: the same or different from one another and each represents H or the like. Provided that R³ does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R⁴ represents a group other than Me when m is 1, R¹ is OH or OMe and Alk₁ is a C_1-3 alkylene, and further 1) when X is a bond, n is 1 and R³ is H, or 2) when X is a bond, n is 0 and R³ is cyclohexane.)