发明名称 |
PREPARATION OF SUBSTITUTED BUTENOLIDES VIA PALLADIUM-FREE ETHERIFICATION AND AMINATION OF MASKED MUCOHALIC ACIDS |
摘要 |
Methods and materials for preparing 4-substituted-2-buten-4-olidos are disclosed. The methods include reacting a masked mucohalic acid with a primary or secondary amine or with an arylol in the presence of a base. Unlike existing processes, the disclosed methods do not require the use of palladium, which make them well suited for preparing intermediates in drug syntheses.
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申请公布号 |
WO2005026141(A8) |
申请公布日期 |
2005.06.30 |
申请号 |
WO2004IB02884 |
申请日期 |
2004.09.06 |
申请人 |
WARNER-LAMBERT COMPANY LLC;BLAZECKA, PETER, GARTH;ZHANG, JI |
发明人 |
BLAZECKA, PETER, GARTH;ZHANG, JI |
分类号 |
C07D307/60;C07D307/66;(IPC1-7):C07D307/60 |
主分类号 |
C07D307/60 |
代理机构 |
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主权项 |
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地址 |
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