摘要 |
A chemically marked procaine penicillin is provided as an antibiotic which can be distinguished from procaine used for anesthetic purposes. A preferred embodiment provides a procaine penicillin molecule wherein the procaine portion of the molecule comprises one or more substituted deuterium atoms in place of hydrogen atoms typically found in procaine penicillin. The resulting non-radioactive isotope can be easily identified via mass spectrometry as being distinct from any naturally occurring isotope, without negatively impacting the pharmacological nature of the drug itself. An alternative embodiment of the invention provides a method of marking the procaine penicillin through the substitution of various other isotopes in place of their naturally occurring counterparts. Methods of detection of the marked procaine penicillin molecule are also provided. |