发明名称 |
DDR2 PROTEIN WITH ACTIVATED KINASE ACTIVITY AND PREPARATION METHOD THEREOF |
摘要 |
<p>The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase activity by inducing phosphorylations of tyrosines by a co-expression with Src or Src related proteins in host cells, or by H2O2 processing of host cells, or a site directed mutation modifying at least one of tyrosines to other amino acid; and a use thereof as a target material in developing medical drugs for treating a disease caused by an excessively activated DDR2 autophosphorylation and tyrosine kinase activity.</p> |
申请公布号 |
WO2005042577(A1) |
申请公布日期 |
2005.05.12 |
申请号 |
WO2004KR02784 |
申请日期 |
2004.11.01 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY;JEIL PHARMACEUTICAL. CO., LTD.;YANG, BEOM-SEOK;PARK, SUNG-DAE |
发明人 |
YANG, BEOM-SEOK;PARK, SUNG-DAE |
分类号 |
C07K14/705;C12N9/12;(IPC1-7):C07K14/705 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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