发明名称 |
POLYPEPTIDES INCLUDING MODIFIED CONSTANT REGIONS |
摘要 |
Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an FcgR, which processes comprise modifying the polypeptides by substitution of the amino acid at position 268 of a human IgG CH2 region for a non-native polar or charged amino acid e.g. Gln, Asn, Glu, or Asp. also provided are corresponding polypeptides, nucleic acids, and methods of use of the same e.g. in improved lytic therapies. |
申请公布号 |
WO2005040217(A2) |
申请公布日期 |
2005.05.06 |
申请号 |
WO2004GB04254 |
申请日期 |
2004.10.07 |
申请人 |
CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED;ARMOUR, KATHRYN, LESLEY;CLARK, MICHAEL, RONALD |
发明人 |
ARMOUR, KATHRYN, LESLEY;CLARK, MICHAEL, RONALD |
分类号 |
C07K16/00;C07K16/34 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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