Use of tetracyclic derivatives for the manufacture of a medicament for treating female sexual dysfunction

摘要

Use of tetracyclic derivatives of general formula (I) and pharmaceutically acceptable salts and solvates (e. g. hydrates) thereof, in which R0 represents H, halogen or alkyl containing 1 to 6 carbon atoms; R1 represents H, alkyl containing 1 to 6 carbon atoms, alkenyl or alkynyl, each of them containing 1 to 6 carbon atoms, haloalkyl containing 1 to 6 carbon atoms, cykloalkyl containing 3 to 8 carbon atoms, cykloalkylalkyl containing 3 to 8 carbon atoms in the cykloalkyl moiety and 1 to 3 carbon atoms in the alkyl moiety, an optionally substituted phenylalkyl containing 1 to 3 carbon atoms in the alkyl moiety or an optionally substituted heteroarylalkyl containing 1 to 3 carbon atoms in the alkyl moiety, wherein heteroaryl is represented by thienyl, furyl or pyridyl; R2 represents an optionally substituted monocyclic aromatic ring selected from benzene, thiophene, furan and pyridine or an optionally substituted bicyclic system; and R3 represents H or alkyl containing 1 to 3 carbon atoms; or R1 and R3 together represent a 3- or 4-membered alkyl or alkenyl chain; for the manufacture of a medicament for the treatment or prophylaxis of female sexual dysfunction such as orgasmic dysfunction. The medicament is preferably in the form suitable for oral administration.