发明名称 |
Methods of modulating activity of DXR |
摘要 |
A method of modulating the activity of a Haemophilus influenzae DXR reductoisomerase enzyme, involving contacting a DXR reductoisomerase enzyme with a compound that inhibits non-mevalonate isoprenoid biosynthesis by lowering or preventing the biosynthesis of either menaquinone or ubiquinone. Pharmaceutical compositions containing such compounds may be used to treat infections. Also provided are methods for utilizing DXR polypeptides and polynucleotides to screen for antibacterial compounds.
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申请公布号 |
US2005096255(A1) |
申请公布日期 |
2005.05.05 |
申请号 |
US20040818210 |
申请日期 |
2004.04.05 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
JAWORSKI DEBORAH D.;PAYNE DAVID J.;SLATER-RADOSTI COURTNEY E.;YAN KANG |
分类号 |
A61K38/00;C07K14/285;C12N9/04;(IPC1-7):A61K38/54;A61K31/12;C12N9/99;C12N9/64 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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