发明名称 |
PROCESS FOR THE PREPARATION OF SIMVASTATIN |
摘要 |
Highly pure simvastatin can be prepared economically in a high yield using the method comprising the steps of treating lovastatin with potassium hydroxide dissolved in a mixture of water and methanol to obtain a triol acid; relactonizing the triol acid, and protecting the hydroxy group on the lactone ring; and acylating the resulting compound with 2,2-dimethylbutyryl chloride or 2,2-dimethylbutyryl bromide in the presence of an acylation catalyst in an organic solvent, followed by removing the silyl protecting group on the lactone ring to obtain simvastatin. |
申请公布号 |
EP1463723(A4) |
申请公布日期 |
2005.04.27 |
申请号 |
EP20020793514 |
申请日期 |
2002.12.26 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
LEE, JAEHEON;HA, TAEHEE;PARK, CHULHYUN;LEE, HOECHUL;LEE, GWANSUN;CHANG, YOUNGKIL |
分类号 |
C07D309/06;A61K31/366;A61P3/06;A61P25/28;C07D309/30;C07F7/18 |
主分类号 |
C07D309/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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