发明名称 Compounds for modulating cell proliferation
摘要 The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Formula (I), (II), wherein R<SUP>1</SUP>, R<SUP>2 </SUP>and R<SUP>3 </SUP>are each independently selected from H, OH, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxy, NH<SUB>2</SUB>, NH-C<SUB>1-6</SUB>alkyl, N(C<SUB>1-6 </SUB>alkyl), SH, S-C<SUB>1-6 </SUB>alkyl, NO<SUB>2</SUB>, CF<SUB>3</SUB>, OCF<SUB>3 </SUB>and halo; R<SUP>4 </SUP>is unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxy and halo; X is selected from (CH<SUB>2</SUB>CH<SUB>2</SUB>O)<SUB>n </SUB>and (CH<SUB>2</SUB>)<SUB>n</SUB>, and n=1-4.
申请公布号 US2005085538(A1) 申请公布日期 2005.04.21
申请号 US20040501699 申请日期 2004.07.16
申请人 ROIFMAN CHAIM M.;DEMIN PETER;GRUNBERGER THOMAS;ROUNOVA OLGA;CIMPEAN OCTAVIAN L. 发明人 ROIFMAN CHAIM M.;DEMIN PETER;GRUNBERGER THOMAS;ROUNOVA OLGA;CIMPEAN OCTAVIAN L.
分类号 C07D213/70;A61K31/165;A61K31/216;A61K31/222;A61K31/265;A61K31/277;A61K31/4402;A61P35/00;A61P35/02;C07C255/23;C07C255/38;C07C255/41;C07C309/67;C07C309/73;C07C317/44;C07C317/46;(IPC1-7):A61K31/277 主分类号 C07D213/70
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