UN PROCEDIMIENTO PARA LA OBTENCION DE NUEVAS DIBENZO (B,F) (1,4) OXACEPIN 11(10H)-ONAS SUSTITUIDAS EN POSICION 10.

摘要

1,170,322. Sedative &c. compositions. DR. KARL THOMAE G.m.b.H. 27 Jan., 1967 [28 Jan., 1966], No. 4283/67. Heading A5B. [Also in Division C2] Pharmaceutical compositions, suitable for oral, parenteral or rectal administration comprise as active ingredient at least one novel compound and/or at least one non-toxic acid addition salt of such compounds as are basic of the formula I wherein R1, R2,' R3 and R4, which can have the same or different meanings, represent H, halogen, C 1-4 alkyl, alkoxy, alkylthio, acyl, CF 3 or NO 2 , and R5 and R6, which can have the same or different meanings, represent H, C 1-4 alkyl, hydroxyalkyl, cycloalkyl or alkenyl; or one of R5 and R6 is NH 2 or -CONH 2 , or C 1-4 alkyl group substituted by NR7R8, where R7 and R8 are alkyl or together with the N atom form a heterocyclic ring, optionally containing a further heteroatom and/or substituted by a methyl or ethyl or R5 and R6 together with the N atom form a 5- to 7-membered heterocyclic ring, optionally containing an oxygen, sulphur or nitrogen atom and/or be substituted by a methyl, ethyl, hydroxyalkyl, acetoxyalkyl, acyl or aralkyl and A is a straight or branded saturated aliphatic hydrocarbon group, which can be substituted by phenyl groups, together with pharmaceutical carriers or excipients and/or further chemotherapeutic agents, such as a diuretic of the 1,2,4-benzothiodazine-1,1-dioxide type, for example, 6-chloro-3,4-dihydto-3-(5-norbornen-2- yl)-7-sulphamoyl-2H-1, 2, 4-benzothiodiazine-1, 1-dioxide, and/or sedative and/or hypotensive agents, such as reserpine or a barbiturate, for example phenylethyl barbituric acid. The above compositions have sedative, anticonvulsive, analgesic, antipyretic, antiphlogistic, spasmolytic and hypotensive activity and an antistrychnine action.