发明名称 |
Recombinant allergen with reduced ige binding but undiminished t-cell antigenicity |
摘要 |
The present invention relates generally to reagents useful in the immunotherapeutic or immunoprophylactic treatment of allergic diseases. More particularly, the present invention provides modified allergens exhibiting reduced IgE interactivity including reduced IgE production-stimulatory activity, while retaining T-cell antigenicity, which are useful in the immunomodulation of type I allergic disease conditions. The present invention further contemplates a method of immunomodulation of allergic diseases such as type I allergic disease conditions by the administration of modified allergens exhibiting reduced IgE interactivity while retaining T-cell antigenicity.
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申请公布号 |
US2005074464(A1) |
申请公布日期 |
2005.04.07 |
申请号 |
US20040490305 |
申请日期 |
2004.09.22 |
申请人 |
THE UNIVERSITY OF MELBOURNE |
发明人 |
DEWEERD NICOLE;SINGH MOHAN BIR;BHALLA PREM L.;SWOBODA INES |
分类号 |
C12N15/09;A61K39/36;A61P37/08;C07K14/415;C07K16/16;C12N15/13;(IPC1-7):A61K39/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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