GRANULES CONTAINING BIOLOGICALLY ACTIVE SUBSTANCES

摘要

A method for making granules containing a biologically active substance (BAS) whereby the BAS is mixed with a binder to form a powder mixture having a concentration of binder below that which, when the binder is melted, will cause over-wetting of the powder mixture, heating the mixture to a temperature above the melting point of the binder to form an agglomerated powder, and forming granules from the agglomerated powder. The granules may be used to make pharmaceutical dosage forms such as tablets and capsules.