发明名称 |
1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVE |
摘要 |
<p>A novel compound which is a 1,3-dihydro-2H-indol-2-one derivative represented by the formula (1): (1) (wherein R1 represents halogeno, C1-4 alkyl, etc. and R2 represents hydrogen, halogeno, etc., or R2 is present in the 6-position of the indol-2-one and is bonded to R1 to form C3-6 alkylene; R3 represents halogeno, hydroxy, etc. and R4 represents hydrogen, halogeno, C1-4 alkyl, etc., or R4 is present in the 3-position of the phenyl and is bonded to R3 to form methylenedioxy; R5 represents hydrogen or fluorine; R6 represents ethylamino, dimethylamino, etc.; R7 represents C1-4 alkoxy; and R8 represents C1-4 alkoxy) or a pharmaceutically acceptable salt of the derivative. The compound has antagonistic activity against an aruginine-vasopressin V1b receptor.</p> |
申请公布号 |
WO2005021534(A1) |
申请公布日期 |
2005.03.10 |
申请号 |
WO2004JP12398 |
申请日期 |
2004.08.27 |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD.;KUMAGAI, TOSHIHITO;KUWADA, TAKESHI;SHIBATA, TSUYOSHI;HAYASHI, MASATO;FUJISAWA, YURI;SEKIGUCHI, YOSHINORI |
发明人 |
KUMAGAI, TOSHIHITO;KUWADA, TAKESHI;SHIBATA, TSUYOSHI;HAYASHI, MASATO;FUJISAWA, YURI;SEKIGUCHI, YOSHINORI |
分类号 |
A61K31/404;A61P1/00;A61P1/14;A61P3/00;A61P7/02;A61P9/00;A61P9/12;A61P17/14;A61P25/08;A61P25/14;A61P25/16;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P29/00;A61P37/02;A61P43/00;C07D403/04;(IPC1-7):C07D403/04;C07M7/00 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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