发明名称 |
COMPOSITIONS AND METHODS OF TREATING AND DIAGNOSING HEPATOMA |
摘要 |
Disclosed are pharmaceutical compositions and methods of treating hepatoma by administering to patients or other populations of cells agents that selectively inhibit the uptake of glutamine by hepatocarcinoma cells, causing the concomitant apoptosis of hepatocarcinoma cells. Preferred agents target the amino acid transporter B0 (ATB0) protein for inhibition. Disclosed are antisense polynucleotides that reduce the expression of ATB0 in hepatocarcinoma cells, causing those cells to reduce the uptake of glutamine and subsequently undergo selective apoptosis. |
申请公布号 |
WO2005020888(A2) |
申请公布日期 |
2005.03.10 |
申请号 |
WO2004US21101 |
申请日期 |
2004.06.30 |
申请人 |
BODE, BARRIE;FUCHS, BRYAN;SAINT LOUIS UNIVERSITY |
发明人 |
BODE, BARRIE;FUCHS, BRYAN |
分类号 |
A61K;C12N15/12;G01N33/574 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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