USE OF TYROSINE KINASE INHIBITORS FOR TREATING CEREBRAL ISCHEMIA

摘要

The present invention relates to a method for treating cerebral ischemia, comprising administering a compound capable of depleting mast cells or a compound inhibiting mast cells degranulation to a human in need of such treatment. Such compounds can be chosen from tyrosine kinase inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3. Preferred compounds are 2<->(3-amino)arylamino-4-aryl-thiazoles or 4<->(4<->methylpiperazine<->l<->ylmethyl)<->N-[4-methyl-3-(4-pyridine-3-yl)pyrimidine-2­ylamino)phenyl]benzamide(imatinib).