发明名称 |
COMPOSITIONS CONTAINING MACROPHAGES AND USES THEREOF |
摘要 |
<p>The invention relates to the use of macrophages for the preparation of a drug for the treatment of a disease or of a lesion involving cellular apoptosis, reduction of the survival of cells and/or destruction of cells. The present invention also provides the use of macrophages for the preparation of a drug for the improvement of survival of a first type of cells, for the treatment of a disease or of a lesion involving the destruction of a second type of cells or of a tissue containing a second type of cells, said first type of cells being chosen among the group consisting of: precursor cells, stem cells and any type of differentiated cells. The inventors surprisingly showed that macrophages may inhibit precursor cells apoptosis in a cell to cell contact and may serve as stromal support for efficient cellular engraftment for tissue repair. They showed in particular that macrophages could inhibit myogenic precursor cell apoptosis.</p> |
申请公布号 |
WO2005014015(A1) |
申请公布日期 |
2005.02.17 |
申请号 |
WO2003EP07731 |
申请日期 |
2003.07.16 |
申请人 |
I.D.M. IMMUNO-DESIGNED MOLECULES;I.N.S.E.R.M. (INSTITUT NATIONAL DE LA SANTE ET DE;CHAZAUD, BENEDICTE;GHERARDI, ROMAIN;HITTINGER, LUC;TEIGER, EMMANUEL |
发明人 |
CHAZAUD, BENEDICTE;GHERARDI, ROMAIN;HITTINGER, LUC;TEIGER, EMMANUEL |
分类号 |
A61K35/14;A61K35/34;A61P9/04;A61P9/10;C12N5/08;(IPC1-7):A61K35/14;C12N5/06 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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