摘要 |
Disclosed are compounds which are tripeptides of the formula P-A-B-C or prodrugs thereof, wherein A is an amino acid having a carboxy alkyl group (e.g., carboxy C1-C6 alkyl group), B is tyrosine, phenylalanine, or a substituted tyrosine or phenylalanine, C is a hydrophobic amino acid, and P is an amine protecting group protecting the amine end of A. Also disclosed are pharmaceutical compositions comprising such a compound and a pharmaceutically acceptable carrier, and a method of treating an animal, e.g., a human, exposed to or infected by Yersihia pestis. The compounds find use as anti-bioterrorism agents. |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;BURKE, TERRENCE, R., JR.;LEE, KYEONG;GAO, YANG;PHAN, JASON;WAUGH, DAVID, S. |
发明人 |
BURKE, TERRENCE, R., JR.;LEE, KYEONG;GAO, YANG;PHAN, JASON;WAUGH, DAVID, S. |