New lysyl-aspartyl-valyl peptides or their conjugates, useful for treating or preventing alopecia, administered topically, orally or as food additive

摘要

Specific peptides (I), or their conjugates (II), as enantiomers or diastereoisomers, also their mixtures, including racemates, optionally as a complex with zinc, are new : Peptides of formula (I), or their conjugates of formula (II), as enantiomers or diastereoisomers, also their mixtures, including racemates, optionally as a complex with zinc, are new W-Lys-Asp-Val-Z (I), A-W-Lys-Asp-Val-Z (II) A : radical of acid R-COOH (III), (dihydro)lipoic acid, N-lipoyl-lysine or retinoic acid; W : Glu-Gln-Arg, Arg-Lys, Arg-Lys-Asp, Arg or bond (Wa) or Gly-Gln-Gln or Glu-Gln (Wb); Z : Tyr-Val-Gln-Leu-Tyr-NH 2, Leu-DOPA, DOPA-NH 2 or homoPhe-NH 2 when W = Wa, or Tyr-Val-Gln-Leu-Tyr-NH 2, Leu-DOPA, Val-Tyr-OH, Val-Tyr-NH 2, Tyr-NH 2, Tyr-OH, DOPA-NH 2 or homoPhe-NH 2 when W = Wb; and R : 1-24C linear or branched aliphatic residue, optionally substituted by hydroxy and optionally containing 1-6 unsaturations. An independent claim is also included for a food supplement that contains (I) and (II), optionally together with a compound (X) that improves regrowth of hair. ACTIVITY : Endocrine-Gen. Anagen-phase mouse whisker follicles were cultured (by the method of J. Dermatol. Sci., 7 (1994) S55) in medium containing 10 -> 7> M of the peptide acetyl-Arg-Lys-Asp-Val-homoPhe-NH 2. Growth (no units stated) was 1.87 after 4 days; contrast 0.55 for a control without the peptide. MECHANISM OF ACTION : None given.