Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension

摘要

Oxadiazole derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new (where R1-5 are each H, halogen, or alkyl, or 2 adjacent gps. together with the benzene nucleus may form a naphthalene system, and 2 of R1-5 are not H when R is NH2; R is -NR'R" or -N=CR'3-NR'1R'2; R' is H, dialkylaminoalkyl, hydroxyalkyl, dialkylamino-alkoxycarbonyl, pyridinoalkyl or alkyl; R" is H or alkyl; R'3 is H, alkyl, aryl or aralkyl; R'1 and R'2 are each alkyl, hydroxyalkyl or dialkylamino-alkyl; or -NR'R" or -NR'1R'2 may form a heterocycle opt contg. another heteroatom which may be substd. by alkyl; all alkyl gps. are 1-4C). (I) are antihypertensives, useful in treatment of essential or secondary hypertension, and have negligible sedative activity. Doses are e.g. 4-100 mg p.o/day.