发明名称 |
METHOD FOR SIMPLIFIED PRODUCTION OF (3-CHLORO-4-FLUORO-PHENYL)-[7-(3-MORPHOLINO-4-YL-PROPOXY)-6-NITRO-QUINAZOLINE-4-YL]-AMINE OR (3-CHLORO-4-FLUORO-PHENYL)-[7-(3-MORPHOLINO-4-YL-PROPOXY)-6-AMINO-QUINAZOLINE-4-YL]-AMINE |
摘要 |
1. Process for the preparation of (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine (I) or of (3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-aminoquinazolin-4-yl]-amine (VII) characterised in that, in a one-pot reaction, in 3 or 4 reaction steps, one first reacts 7-fluoro-6-nitroquinazolin-4(3H)-one (III) with thionyl chloride to give 4-chloro-7-fluoro-6-nitroquinazoline (IV) reacts this with 3-chloro-4-fluoroaniline to give 4-(3-chloro-4-fluoroanilino)-7-fluoro-6-nitroquinazoline (V) and subsequently with 3-morpholin-4-yl-propan-1-ol (VI) to give (I) and possibly hydrogenates (I) directly in the reaction solution to give (III).
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申请公布号 |
EA005213(B1) |
申请公布日期 |
2004.12.30 |
申请号 |
EA20020000885 |
申请日期 |
2001.01.23 |
申请人 |
GOEDECKE GMBH |
发明人 |
BARTH, HUBERT;STEINER, KLAUS;SCHNEIDER, SIMON |
分类号 |
C07D239/94;(IPC1-7):C07D239/94 |
主分类号 |
C07D239/94 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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