ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES

摘要

Compounds of formula (I): A-(X1-ONO2)S wherein A is a known ACE-inhibitor su ch as enalapril and X1 is a spacer such as a (C1-C6)-alkylene. The complete definition of A and X1 is given in claim 1. The compounds can be used as ACE - inhibitors for the treatment of cardiovascular and renal diseases and inflammatory processes. The example of formula (1) has an improved pharmacological activity when compared with the structurally closest related prior art compound.