| 发明名称 |
Nucleotide analogs |
| 摘要 |
Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
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| 申请公布号 |
US2004242465(A1) |
申请公布日期 |
2004.12.02 |
| 申请号 |
US20040882022 |
申请日期 |
2004.06.29 |
| 申请人 |
BISCHOFBERGER NORBERT W.;JONES ROBERT J.;ARIMILLI MURTY N.;LIN KUEI-YING;LOUIE MICHAEL S.;MCGEE LAWRENCE R.;PRISBE ERNEST J.;LEE WILLIAM A.;CUNDY KENNETH C. |
发明人 |
BISCHOFBERGER NORBERT W.;JONES ROBERT J.;ARIMILLI MURTY N.;LIN KUEI-YING;LOUIE MICHAEL S.;MCGEE LAWRENCE R.;PRISBE ERNEST J.;LEE WILLIAM A.;CUNDY KENNETH C. |
| 分类号 |
C07F9/6512;C07F9/6561;C07F9/6571;C07F9/6574;C07F9/6578;C07H19/10;C07H19/20;(IPC1-7):A61K38/16;A61K31/707;A61K31/675 |
主分类号 |
C07F9/6512 |
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