| 摘要 |
<p>Human hepatoma cell lines (A) that can be infected naturally with (i) parasites, hepatotropic or not, e.g. Plasmodium or Leishmania or (ii) viruses. They express receptors for Flaviviridae and Hepadnaviridae, particularly hepatitis B and C viruses. Independent claims are also included for the following: (1) human hepatoma cell lines (B) that: (i) can differentiate to cells having morphology similar to that of liver cells (hepatocytes and/or biliary cells); (ii) express functions characteristic of hepatocytes; or (iii) in the proliferative stage, have the properties of pluripotent cells; (2) cells and their components derived from (A) or (B); (3) selecting (A) or (B); (4) infecting hepatic cells with a hepatotropic parasite or virus; (5) transforming (A), (B) or the cells of (2) with a vector containing at least part of the genetic material of hepatitis B or C virus (HBV, HCV); (6) use of specific medium (X) for maintaining stability of (A), (B) or the cells of (2); (7) antibodies (Ab) directed against Flaviviridae or Hepadnaviridae obtained from (A), (B) or the cells of (2); (8) viral neutralization test; (9) vaccine containing viral particles and/or polypeptides obtained by infection or transfection of (A), (B) and/or cells of (2); and (10) evaluating virucidal activity of chemical disinfectants. ACTIVITY : Virucide; Hepatotropic; Antiinflammatory. No relevant biological data is given. MECHANISM OF ACTION : Vaccine.</p> |
