| 摘要 |
PROBLEM TO BE SOLVED: To provide a simple method for producing (4R,6S)-6-benzyloxymethyl-4-hydroxy-tetrahydro-2-pyrone represented by formula (3) useful as a synthetic intermediate for HMG-CoA reductase inhibiting antihyperlipidemic. SOLUTION: Benzyloxyacetaldehyde is reacted with acetaldehyde in the presence of aldolase comprising an aromatic ring-containing aldehyde as a substrate to produce 6-O-benzyl-2,4-dideoxy-D-erythro-hexose represented by formula (2) (R is a cyano group, a hydroxy group, a halogen atom, a 1-6C alkyl group or a 1-6C alkoxy group; n is an integer of 0-5), which is oxidized to give (4R,6S)-6-benzyloxymethyl-4-hydroxy-tetrahydro-2-pyrone represented by formula (3). COPYRIGHT: (C)2005,JPO&NCIPI
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