发明名称 |
Compounds and methods for modulating desmosomal cadherin-mediated functions |
摘要 |
Modulating agents for inhibiting or enhancing desmosomal cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50% identical to a desmosomal cadherin CAR sequence; (b) a non-peptide mimetic of a desmosomal cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a desmosomal cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a desmosomal cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating desmosomal cadherin-mediated cell adhesion in a variety of contexts are also provided.
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申请公布号 |
US2004229811(A1) |
申请公布日期 |
2004.11.18 |
申请号 |
US20030654578 |
申请日期 |
2003.09.03 |
申请人 |
ADHEREX TECHNOLOGIES, INC. |
发明人 |
BLASCHUK OREST W.;SYMONDS JAMES MATTHEW;GOUR BARBARA J. |
分类号 |
A61K38/00;C07K5/083;C07K5/103;C07K7/06;C07K14/705;(IPC1-7):A61K38/10;A61K38/08;A61K38/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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