OPTICAL RESONATOR DIAGNOSTIC DEVICE AND METHODS OF USE

摘要

An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

主权项

1. A diagnostic device fabricated in silicon, the diagnostic device comprising:
an array of optical resonators, each optical resonator comprising an immunoassay site; an optical waveguide configured for coupling coherent light into one or more optical resonators in the array of optical resonators; and an array of detectors optically coupled to the array of optical resonators, each detector in the array of detectors configured to detect: a) a first resonant wavelength generated by a corresponding optical resonator, and b) a second resonant wavelength generated by the corresponding optical resonator upon undergoing a change in refractive index by binding of at least one molecule to the immunoassay site.